To configure pgadmin with Apache and uwsgi, just add the follwing lines to a vhost: ProxyPass /pgadmin unix:/run/uwsgi/uwsgi-pgadmin.sock|uwsgi://localhost/ <Directory PYTHONSITELIB/pgadmin4-web/> Require all granted </Directory> Note that you have to run once `pgadmin4` from the command line to set the master password by executing: /usr/bin/python3 PYTHONSITELIB/pgadmin4-web/pgAdmin4.py